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KMID : 0043320140370111375
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Archives of Pharmacal Research
2014 Volume.37 No. 11 p.1375 ~ p.1379
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Cytotoxic dibenzocyclooctadiene lignans from Kadsura coccinea
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Zhao Qing Jie
Song Yan
Chen Hai Sheng
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Abstract
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Three new dibenzocyclooctadiene lignans, kadusurain A?C (1?3), together with two known compounds kadsuphilin A (4) and B (5), were isolated from an EtOAc fraction of the 80 % acetone extract of Kadsuracoccinea (Lem.) A. C. Smith. Their structures were established by 1D and 2D NMR techniques, and mass spectroscopy. Anti-proliferative effect of isolated compounds was evaluated against four human tumor cell lines (A549, HCT116, HL-60, and HepG2), and it was found that compound 1 exhibited significant antiproliferative effects with IC50 values ranging from 1.05 to 12.56 μg/ml.
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KEYWORD
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Kadsura coccinea, Schisandraceae, Dibenzocyclooctadiene lignans, Cytotoxic activity
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